NanoVIVO™ PLGA Nanoparticle Line
Our single-layer poly (lactic-co-glycolic acid) (PLGA) nanoparticles form nanostructures with a hydrophobic core encapsulated inside a hydrophilic shell. Dye molecules and magnetic nanoparticles can be encapsulated inside the hydrophobic core. PLGA surface contains COOH groups that can be used for EDC/NHS based bioconjugation. Optional surface modifications include methoxy PEG (improves in vivo blood half-life) and PEG-Azide (can be used to covalently attach biomolecules by click chemistry)
Features:​​
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120 - 170 nm diameter PLGA nanoparticles.
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Made with FDA approved biocompatible and biodegradable PLGA polymer.
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Conjugation-ready for covalent attachment of biomolecules.
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High degree of monodispersity.
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Magnetic version can be pulled down by application of magnetic force.
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Can be labeled with a fluorescent dye.
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Optional incorporation of Methoxy-PEG minimizes non-specific protein adsorption. This increase nanoparticle in-vivo blood half-life.
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Custom formulations for encapsulation of specific payloads are available.
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Applications:
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Dual labeled fluorescence and magnetic nanoparticles for in-vivo targeting.
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Dual fluorescence and MRI imaging for in vitro and in vivo applications.
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Dual probes for magnetic cell pulldown and flowcytometry analysis.
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Contact us at info@lunanano.com for more information or to inquire about custom PLGA nanoparticle synthesis.
