Dextran CLIO Magnetic Nanoparticles - Biotin, Fluorescent Dye

General Information
Fluorescent, Biotin functionalized Dextran coated crosslinked iron oxide nanoparticles (CLIO-BIOTD) have 1-3 superparamagnetic Fe3O4 iron oxide cores (8-10 nm in diameter) imbedded within the matrix of dextran strands of 40 or 70 kDa in size. Dextran strands are crosslinked to prevent their disassociation, ensuring long-term stability. Biotin and fluorescence dye are covalently conjugated to the nanoparticle surface.
 
Features
Superparamagnetic
Fluorescently labeled (AFDye 488, AFDye 555, AFDye 647, or IR750 dye)
Highly biocompatible, non-toxic
Long term stable under physiological conditions
40 kDa and 70 kDa dextran coats are available
Easy loading of biomolecules such as Antibodies through Streptavidin-Biotin interaction
 
Applications
 
In vitro and in vivo dual magnetic and fluorescence labels for cells and tissues.
Magnetic, fluorescence, or dual cell separation.
Probes for MRI.
 
Specifications
Iron Oxide Core Diameter: 8 – 10 nm
Hydrodynamic Diameter: 50 – 110 nm
Polydispersity Index (PDI): < 0.3
Magnetization:  5 – 30 emu/g (room temperature)
Fluorescent Dye:
AFDye 488 (AlexaFluor 488 analog, Abs/Em = 490/525, Filter set: FITC)
AFDye 555 (AlexaFluor 555 analog, Abs/Em = 555/580, Filter set: TRITC)
AFDye 647 (AlexaFluor 647 analog, Abs/Em = 650/665, Filter set: Cy5)
IR750 (IRDye 750 analog, Abs/Em = 756/776, Filter set: Cy7)
Shelf life: > 1 year (4°C storage)
Supplied as liquid suspension in water