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NanoVIVO™  Magnetic CLIO Nanoparticle Line

Dextran coated magnetic cross-linked iron oxide nanoparticles (CLIO) have superparamagnetic Fe3O4 iron oxide core (8-10 nm in diameter) imbedded within the matrix of dextran sugar strands of 40 or 70 kDa in size. Dextran strands are cross-linked to prevent their disassociation, ensuring long-term stability during storage and in biological fluids, such as blood. Due to the dextran sugar coat CLIO particles are highly biocompatible and have a long blood half life, making them optimal for both in vitro and in vivo applications


CLIO nanoparticles are available with a variety of surface chemistries that can be used for bioconjugation of biological ligands for a range of biomedical applications:​​

  • Loading antibodies and other biomolecues through Biotin-Streptavidin interaction or EDC/NHS chemical reaction.​​​

  • Fluorescently labeled CLIO nanoparticles can be used as dual magnetic and fluorescence imaging and MRI probes.

  • CLIO nanoparticles can be used to target specific cells and tissues in vivo, or for development of in vitro bioassays.​

  • Dual fluorescence-magnetic probes for cell separation, flow cytometry, fluorescence associated cell sorting (FACS)​.

More detailed information on nanoparticle functionalization can be found here. Please contact us if you do not see a specific surface chemistry needed for your application. We are always willing to work with our customers to develop new surface functionalizations.


Magnetic CLIO Nanoparticle Products

Fluorescently Labeled Magnetic CLIO Nanoparticle Products


Fluorescent molecules are directly conjugated to the nanoparticle surface. Our standard dyes include AFDye 488, Cy3, Cy5, and IR 750. AFDye 488 and IR 750 are mimics of AlexaFluor® 488 and IRDye® 750 with very similar structure and spectral properties. Functionalizations with other dyes are available upon request.

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